Instituto de Investigação e Inovação em Saúde, Universidade do Porto

Rua Alfredo Allen, 208 4200-135 Porto, Portugal
Phone: +351 226 074 900
Email: info@i3s.up.pt

Category research

New ICG article published in Carbohydrate Research on the role of glycans in trained immunity

Pinho’s lab has recently published a review article in the journal Carbohydrate Research. Trained immunity is an emerging concept in immunology and in this publication, first authored by Pedro Almeida, we highlight its tenets and delve into how glycans and their interactions with glycan-binding proteins (GBPs) influence key immunoregulatory networks in trained immunity.

New ICG article published in Nature Immunology identifies early IgG glycosylation alterations in Crohn’s Disease

Exciting news! In our most recent publication, we unveil a novel glycan signature in serum IgG antibodies years before the diagnosis of Crohn’s disease. In addition to predating Crohn’s disease and being associated with its complications, we show how this glycan signature elicits pro-inflammatory immune responses and contributes to disease susceptibility.

New ICG article published Portuguese Journal of Gastroenterology (GE) – Glycosylation profile as a potential biomarker for colorectal cancer progression

Exciting news! In a significant stride towards understanding colorectal cancer (CRC) progression, a recent study by our research group investigated the intricate role of glycosylation in serrated pathway lesions (SPLs), a specific pathway associated with colorectal cancer development. Published in…