Category publication

Pinho´s Lab publishes Nature Review Article on the mucosal glycome in inflammatory bowel disease

Pinho’s Lab has recently published a landmark review in the journal Nature Reviews Gastroenterology & Hepatology!  In collaboration with Joana Torres (Luz Hospital, Lisbon) and Jean-Frederic Colombel (Ichan School of Medicine, Mount Sinai, NYC, USA), this publication delves into how the mucosal glycome encodes a complex layer of biological information that actively contributes to gut homeostasis and disease.

New ICG article published in Gut on the impact of environmental pollutants in IBD

This study, published in the journal Gut, focuses on how environmental pollutants influence the risk of developing inflammatory bowel disease as well as disease outcomes. In total, information from a total of 32 human studies was utilized, allowing for a consolidation of the current knowledge on how escalating pollution levels relate to the increasing incidence of IBD globally.

New ICG article published in Carbohydrate Research on the role of glycans in trained immunity

Pinho’s lab has recently published a review article in the journal Carbohydrate Research. Trained immunity is an emerging concept in immunology and in this publication, first authored by Pedro Almeida, we highlight its tenets and delve into how glycans and their interactions with glycan-binding proteins (GBPs) influence key immunoregulatory networks in trained immunity.

New ICG article published in Nature Immunology identifies early IgG glycosylation alterations in Crohn’s Disease

Exciting news! In our most recent publication, we unveil a novel glycan signature in serum IgG antibodies years before the diagnosis of Crohn’s disease. In addition to predating Crohn’s disease and being associated with its complications, we show how this glycan signature elicits pro-inflammatory immune responses and contributes to disease susceptibility.

New ICG article published Portuguese Journal of Gastroenterology (GE) – Glycosylation profile as a potential biomarker for colorectal cancer progression

Exciting news! In a significant stride towards understanding colorectal cancer (CRC) progression, a recent study by our research group investigated the intricate role of glycosylation in serrated pathway lesions (SPLs), a specific pathway associated with colorectal cancer development. Published in…