Instituto de Investigação e Inovação em Saúde, Universidade do Porto
Rua Alfredo Allen, 208 4200-135 Porto, Portugal
Phone: +351 226 074 900
Email: info@i3s.up.pt
Inês Alves has recently been awarded with an ECCO Grant!
This work will contribute to the discovery of novel mechanism and therapeutic targets at the interface of health-to-disease transition.
Pinho’s Lab is proud to announce that Daniela Oliveira has been awarded the SPR/Fresenius Grant, funded by the Portuguese Society of Rheumatology. The grant will support her PhD project, “GUT-JOINT AXIS STUDY – Antimicrobial antibodies as mediators of the gut–joint axis: the role of gut glycosylation and intestinal permeability in patients with Spondyloarthritis.”
Pinho’s Lab has recently published a landmark review in the journal Nature Reviews Gastroenterology & Hepatology! In collaboration with Joana Torres (Luz Hospital, Lisbon) and Jean-Frederic Colombel (Ichan School of Medicine, Mount Sinai, NYC, USA), this publication delves into how the mucosal glycome encodes a complex layer of biological information that actively contributes to gut homeostasis and disease.
In our most recent publication in Cancer Immunology Research, we describe how T cell glycosylation mediates T cell exhaustion in colorectal cancer and how engineering of the T cell glycome can boost the anti-tumor activity of CD8+ and CAR-T cells.
Pedro Cabral and Ana Campar have recently been awarded by NEDAI (Núcleo de Estudos de Doenças Auto-Imunes) at its XI National Congress, which also marked the XXX Annual Meeting of Autoimmunity in Portugal. Each was distinguished by their pioneering work in lupus nephritis and idiopathic inflammatory myopathies, respectively.
Pinho’s Lab has recently published a landmark study on colitis-associated colorectal cancer (CAC) in the Journal of Crohn’s and Colitis! Therein, we demonstrate that a progressive increase in N-glycan branching at the T cell surface not only accompanies CAC development but also debilitates T cell function during carcinogenesis.
Exciting news! In our most recent publication, we unveil a novel glycan signature in serum IgG antibodies years before the diagnosis of Crohn’s disease. In addition to predating Crohn’s disease and being associated with its complications, we show how this glycan signature elicits pro-inflammatory immune responses and contributes to disease susceptibility.
Inês Alves, a researcher in Pinho's Lab, has been awarded a prestigious €10,000 Exploratory Research Grant by the European Society for Clinical Investigation (ESCI).
The 2nd GlycanTrigger General Assembly Meeting has concluded successfully in Leiden, The Netherlands. Hosted by Leiden University Medical Center (LUMC), the two-day event brought together researchers and collaborators from all partners across Europe and USA to discuss the latest developments in the project.
Our team at i3s had the pleasure of hosting a progress meeting for the GlycanSwitch ERC project from February 29th to March 1st. With a focus on understanding the role of IgG glycans in inflammatory diseases.