Instituto de Investigação e Inovação em Saúde, Universidade do Porto
Rua Alfredo Allen, 208 4200-135 Porto, Portugal
Phone: +351 226 074 900
Email: info@i3s.up.pt
Our group works at the interface of immunology, cancer and glycobiology, using a combination of in vitro, ex vivo and in vivo approaches.
The group’s research has been published in a number of high-impact publications over the years.
The group’s research explores several topics related to the impact of glycans on inflammation, autoimmunity and cancer.
OUR GROUP MAIN LINES OF RESEARCH:
The exploitation of the cellular and molecular mechanisms by which glycans contribute to amplify immune response in chronic inflammation and autoimmunity.
OUR GROUP MAIN LINES OF RESEARCH:
The investigation of how cancer-specific glycosignatures regulate the immunological networks in cancer.
In our most recent publication in Cancer Immunology Research, we describe how T cell glycosylation mediates T cell exhaustion in colorectal cancer and how engineering of the T cell glycome can boost the anti-tumor activity of CD8+ and CAR-T cells.
Eduarda Leite-Gomes, a PhD Student from Pinho’s Lab, has recently been awarded with a short-term fellowship from the Federation of European Biochemical Societies.
Pedro Cabral and Ana Campar have recently been awarded by NEDAI (Núcleo de Estudos de Doenças Auto-Imunes) at its XI National Congress, which also marked the XXX Annual Meeting of Autoimmunity in Portugal. Each was distinguished by their pioneering work in lupus nephritis and idiopathic inflammatory myopathies, respectively.