Publications

Immunology, Cancer & Glycomedicine

2024

Estevinho MM, Midya V, Cohen-Mekelburg S, Allin KH, Fumery M, Pinho SS, Colombel JF, Agrawal M. (2024) Emerging role of environmental pollutants in inflammatory bowel disease risk, outcomes and underlying mechanisms. Gut 2024. https://doi.org/10.1136/gutjnl-2024-332523

Almeida P, Fernandes Â, Alves I, Pinho SS. (2024) “Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease”. Carbohydr Res. 2024 544:109245 https://doi.org/10.1016/j.carres.2024.109245

Gaifem J*, Rodrigues CS*, Petralia F, Alves I, Leite-Gomes E, Cavadas B, Dias AM, Moreira-Barbosa C, Revés J, Laird RM, Novokmet M, Štambuk J, Habazin S, Turhan B, Gümüş ZH, Ungaro R, Torres J, Lauc G, Colombel JF, Porter CK, Pinho SS. A unique serum IgG glycosylation signature predicts development of Crohn’s disease and is associated with pathogenic antibodies to mannose glycan. Nat Immunol. 2024 25(9):1692-1703. https://doi.org/10.1038/s41590-024-01916-8

2023

Vicente, M. M., Leite-Gomes, E., & Pinho, S. S. (2023). Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications. Trends in immunology, 44(8), 585–597. https://doi.org/10.1016/j.it.2023.06.004

Pinho, S.S., Alves, I., Gaifem, J. et al. Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection. Cell Mol Immunol 20, 1101–1113 (2023). h ttps://doi.org/10.1038/s41423-023-01074-1

Campar, A., Alves, I., Santos-Pereira, B., Nogueira, R., Pinto, M. M., Vasconcelos, C., & Pinho, S. S. (2023). Muscle glycome in Idiopathic Inflammatory Myopathies: impact in IL-6 production and disease prognosis. iScience. https://www.sciencedirect.com/science/article/pii/S258900422301249X

Vicente, M. M., Alves, I., Fernandes, Â., Dias, A. M., Santos-Pereira, B., Pérez-Anton, E., … & Pinho, S. S. (2023). Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity. Cellular & Molecular Immunology, 1-14.https://doi.org/10.1038/s41423-023-01052-7

Alves, Inês; Santos-Pereira, Beatriz; de la Cruz, Noelia; Campar, Ana; Pinto, Vanda; Rodrigues, Pedro M.; Araújo, Marco; et al. “Host-derived mannose glycans trigger a pathogenic γd T cell/IL-17a axis in autoimmunity”. Science Translational Medicine 15 687 (2023): https://www.science.org/stoken/author-tokens/ST-1088/full

Ângela Fernandes; Catarina M. Azevedo; Mariana C. Silva; Guilherme Faria; Carolina S. Dantas; Manuel M. Vicente; Salomé S. Pinho. “Glycans as shapers of tumour microenvironment: A sweet driver of T-cell-mediated anti-tumour immune response”. Immunology (2023): https://doi.org/10.1111/imm.13494.

2022

Mortha, Arthur; Remark, Romain; Del Valle, Diane Marie; Chuang, Ling-Shiang; Chai, Zhi; Alves, Inês; Azevedo, Catarina; et al. “Neutralizing Anti-Granulocyte Macrophage-Colony Stimulating Factor Autoantibodies Recognize Post-Translational Glycosylations on Granulocyte Macrophage-Colony Stimulating Factor Years Before Diagnosis and Predict Complicated Crohn’s Disease”. Gastroenterology 163 3 (2022): 659-670. http://dx.doi.org/10.1053/j.gastro.2022.05.029.
10.1053/j.gastro.2022.05.029

Inês Alves*; Ângela Fernandes*; Beatriz Santos-Pereira; Catarina M. Azevedo; Salomé S. Pinho. “Glycans as a key factor in self and nonself discrimination: impact on the breach of immune tolerance”. FEBS Letters (2022): https://doi.org/10.1002/1873-3468.14347.

2021

Eduarda Leite-Gomes; Ana M Dias; Catarina M Azevedo; Beatriz Santos-Pereira; Mariana Magalhães; Mónica Garrido; Rita Amorim; et al. “Bringing to Light the Risk of Colorectal Cancer in Inflammatory Bowel Disease: Mucosal Glycosylation as a Key Player”. Inflammatory Bowel Diseases (2021): https://doi.org/10.1093/ibd/izab291.

Alves, Inês; Vicente, Manuel Machado; Gaifem, Joana; Fernandes, ngela; Dias, Ana Mendes; Rodrigues, Cláudia Sousa; Oliveira, José Carlos; et al. “SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis”. The Journal of Immunology 207 6 (2021): 1591-1598. http://dx.doi.org/10.4049/jimmunol.2100131

2020

Silva, Mariana C.; Fernandes, ngela; Oliveira, Maria; Resende, Carlos; Correia, Alexandra; de-Freitas-Junior, Julio C.; Lavelle, Aonghus; et al. “Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression”. Cancer Immunology Research 8 11 (2020): 1407-1425. http://dx.doi.org/10.1158/2326-6066.cir-20-0264.

Pereira, Márcia S.; Durães, Cecília; Catarino, Telmo A.; Costa, José L.; Cleynen, Isabelle; Novokmet, Mislav; Krištic, Jasminka; et al. “Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulation of T Cells Glycosylation and Plasma IgG Glycome Composition in Ulcerative Colitis”. Clinical and Translational Gastroenterology 11 4 (2020): e00166. http://dx.doi.org/10.14309/ctg.0000000000000166.

2019

Verhelst, Xavier; Dias, Ana M.; Colombel, Jean-Frederic; Vermeire, Severine; Van Vlierberghe, Hans; Callewaert, Nico; Pinho, Salomé S.. “protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases”. Gastroenterology (2019): http://dx.doi.org/10.1053/j.gastro.2019.08.060.

Pereira, M.S.; Maia, L.; Azevedo, L.F.; Campos, S.; Carvalho, S.; Dias, A.M.; Albergaria, A.; et al. “A [Glyco] biomarker that predicts failure to standard therapy in ulcerative colitis patients”. Journal of Crohn’s and Colitis 13 1 (2019): 39-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057358772&partnerID=MN8TOARS http://www.scopus.com/inward/record.url?eid=2-s2.0-85057358772&partnerID=MN8TOARS.

2018

Rodrigues, J.G.; Balmaña, M.; Macedo, J.A.; Poças, J.; Fernandes, Â.; de-Freitas-Junior, J.C.M.; Pinho, S.S.; et al. “Glycosylation in cancer: Selected roles in tumour progression, immune modulation and metastasis”. Cellular Immunology (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85044285887&partnerID=MN8TOARS.

Dias, A.M.; Pereira, M.S.; Padrão, N.A.; Alves, I.; Marcos-Pinto, R.; Lago, P.; Pinho, S.S.. “Glycans as critical regulators of gut immunity in homeostasis and disease”. Cellular Immunology 333 (2018): 9-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050201106&partnerID=MN8TOARS

Dias, A.M.; Correia, A.; Pereira, M.S.; Almeida, C.R.; Alves, I.; Pinto, V.; Catarino, T.A.; et al. “Metabolic control of T cell immune response through glycans in inflammatory bowel disease”. Proceedings of the National Academy of Sciences of the United States of America 115 20 (2018): E4651-E4660. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046964805&partnerID=MN8TOARS

Klasic, M.; Markulin, D.; Vojta, A.; Samaržija, I.; Biruš, I.; Dobrinic, P.; Ventham, N.T.; et al. “Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease”. Clinical Epigenetics 10 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85048033567&partnerID=MN8TOARS

Pereira, M.S.; Alves, I.; Vicente, M.; Campar, A.; Silva, M.C.; Padrão, N.A.; Pinto, V.; et al. “Glycans as key checkpoints of T cell activity and function”. Frontiers in Immunology 9 NOV (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85057432575&partnerID=MN8TOARS

2017

Pinho, Salomé. “Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression”. International Journal of Molecular Sciences (2017): http://www.mdpi.com/1422-0067/18/9/1921.

Pereira, C.C.; Durães, C.; Coelho, R.; Grácio, D.; Silva, M.; Peixoto, A.; Lago, P.; et al. “Association between polymorphisms in antioxidant genes and inflammatory bowel disease”. PLoS ONE 12 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85008394516 &partnerID=MN8TOAR

2016

Carvalho, S.; Catarino, T.A.; Dias, A.M.; Kato, M.; Almeida, A.; Hessling, B.; Figueiredo, J.; et al. “Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer”. Oncogene 35 13 (2016): 1619-1631. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937605601&partnerID=MN8TOARS

Carvalho, S.; Reis, C.A.; Pinho, S.S.. “Cadherins Glycans in Cancer: Sweet Players in a Bitter Process”. Trends in Cancer 2 9 (2016): 519-531. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989821862&partnerID=MN8TOARS

Carvalho, S.; Oliveira, T.; Bartels, M.F.; Miyoshi, E.; Pierce, M.; Taniguchi, N.; Carneiro, F.; et al. “O-mannosylation and N-glycosylation: Two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer”. Oncotarget 7 40 (2016): 65231-65246. http://www.scopus.com/inward/record.url?eid=2-s2.0-84993660248&partnerID=MN8TOARS

2015

Pinho, S.S.; Reis, C.A.. “Glycosylation in cancer: Mechanisms and clinical implications”. Nature Reviews Cancer 15 9 (2015): 540-555. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940449986&partnerID=MN8TOARS

2014

Dias, A.M.; Dourado, J.; Lago, P.; Cabral, J.; Marcos-Pinto, R.; Salgueiro, P.; Almeida, C.R.; et al. “Dysregulation of T cell receptor N-glycosylation: A molecular mechanism involved in ulcerative colitis”. Human Molecular Genetics 23 9 (2014): 2416-2427. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897565140&partnerID=MN8TOARS

Bassagañas, S.; Carvalho, S.; Dias, A.M.; Pérez-Garay, M.; Ortiz, M.R.; Figueras, J.; Reis, C.A.; Pinho, S.S.; Peracaula, R.. “Pancreatic cancer cell glycosylation regulates cell adhesion and invasion through the modulation of a2ß1 integrin and E-cadherin function”. PLoS ONE 9 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84902337828&partnerID=MN8TOARS.

Nunes, J.B.; Peixoto, J.; Soares, P.; Maximo, V.; Carvalho, S.; Pinho, S.S.; Vieira, A.F.; et al. “OXPHOS dysfunction regulates integrin-ß1 modifications and enhances cell motility and migration”. Human Molecular Genetics 24 7 (2014): 1977-1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926488610&partnerID=MN8TOARS.

2013

De-Freitas-Junior, J.C.M.; Carvalho, S.; Dias, A.M.; Oliveira, P.; Cabral, J.; Seruca, R.; Oliveira, C.; et al. “Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. An interplay with E-cadherin”. PLoS ONE 8 11 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84896731020&partnerID=MN8TOARS

Pinho, S.S.; Figueiredo, J.; Cabral, J.; Carvalho, S.; Dourado, J.; Magalhães, A.; Gärtner, F.; et al. “E-cadherin and adherens-junctions stability in gastric carcinoma: Functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and v”. Biochimica et Biophysica Acta – General Subjects 1830 3 (2013): 2690-2700. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873589547&partnerID=MN8TOARS

Pinho, S.S.; Carvalho, S.; Marcos-Pinto, R.; Magalhães, A.; Oliveira, C.; Gu, J.; Dinis-Ribeiro, M.; et al. “Gastric cancer: Adding glycosylation to the equation”. Trends in Molecular Medicine 19 11 (2013): 664-676. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886951831&partnerID=MN8TOARS

2012

Paredes, J.; Figueiredo, J.; Albergaria, A.; Oliveira, P.; Carvalho, J.; Ribeiro, A.S.; Caldeira, J.; et al. “Epithelial E- and P-cadherins: Role and clinical significance in cancer”. Biochimica et Biophysica Acta – Reviews on Cancer 1826 2 (2012): 297-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861800037&partnerID=MN8TOARS.

Pinho, S.S.; Oliveira, P.; Cabral, J.; Carvalho, S.; Huntsman, D.; Gärtner, F.; Seruca, R.; Reis, C.A.; Oliveira, C.. “Loss and recovery of Mgat3 and GnT-III mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-Mesenchymal-Epithelial transitions”. PLoS ONE 7 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84858138360&partnerID=MN8TOARS

Pinho, S.S.; Carvalho, S.; Cabral, J.; Reis, C.A.; Gärtner, F.. “Canine tumors: A spontaneous animal model of human carcinogenesis”. Translational Research 159 3 (2012): 165-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857276564&partnerID=MN8TOARS

2011

Klopfleisch, R.; von Euler, H.; Sarli, G.; Pinho, S.S.; Gärtner, F.; Gruber, A.D.. “Molecular carcinogenesis of canine mammary tumors: News from an old disease”. Veterinary Pathology 48 1 (2011): 98-116. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951940506&partnerID=MN8TOARS

Pinho, S.S.; Seruca, R.; Gärtner, F.; Yamaguchi, Y.; Gu, J.; Taniguchi, N.; Reis, C.A.. “Modulation of E-cadherin function and dysfunction by N-glycosylation”. Cellular and Molecular Life Sciences 68 6 (2011): 1011-1020. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953721653&partnerID=MN8TOARS

2009

Pinho, S.S.; Osório, H.; Nita-Lazar, M.; Gomes, J.; Lopes, C.; Gärtner, F.; Reis, C.A.. “Role of E-cadherin N-glycosylation profile in a mammary tumor model”. Biochemical and Biophysical Research Communications 379 4 (2009): 1091-1096. http://www.scopus.com/inward/record.url?eid=2-s2.0-58949097354&partnerID=MN8TOARS

Pinho, S.S.; Reis, C.A.; Paredes, J.; Magalhães, A.M.; Ferreira, A.C.; Figueiredo, J.; Xiaogang, W.; et al. “The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin”. Human Molecular Genetics 18 14 (2009): 2599-2608. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649859659&partnerID=MN8TOARS

Pinho, S.S.; Reis, C.A.; Gärtner, F.; Alpaugh, M.L.. “Molecular plasticity of E-cadherin and sialyl lewis X expression, in two comparative models of mammary tumorigenesis”. PLoS ONE 4 8 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-68949159937&partnerID=MN8TOARS

de Oliveira, J.T.; Pinho, S.S.; de Matos, A.J.; Hespanhol, V.; Reis, C.A.; Gärtner, F.. “MUC1 expression in canine malignant mammary tumours and relationship to clinicopathological features”. Veterinary Journal 182 3 (2009): 491-493. http://www.scopus.com/inward/record.url?eid=2-s2.0-71849093863&partnerID=MN8TOARS

2007

Pinho, S.S.; Matos, A.J.F.; Lopes, C.; Marcos, N.T.; Carvalheira, J.; Reis, C.A.; Gärtner, F.. “Sialyl Lewis x expression in canine malignant mammary tumours: Correlation with clinicopathological features and E-Cadherin expression”. BMC Cancer 7 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-34547799601&partnerID=MN8TOARS.